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Cancer immunotherapy: are we there yet?

The immune system is the built-in host defense mechanism against infectious agents as well as cancer. Protective immunity against cancer was convincingly demonstrated in the 1940s with syngeneic animal models (JNCI 18:769-778, 1976; Cancer Immun 1:6, 2001). Since then, the last century's dream has been to effectively prevent and cure cancers by immunological means. This dream has slowly but sur...

Renal tubular acidosis nejm pdf

100 Classics from the New England Journal of Medicine

Recently, we identified the 100 mostcited papers of all time, 1 and indicated which of them were the subjects of Citation C[a~~i~~’”2 ~omment~ries. we now plan to publish a series of essays listing the most-cited articles from several leading multidisciplinary or multispeciaky journals. Publication of these lists constitutes an open invitation to the authors of these Citation Classics to submit...

Success breeds success: authorship distribution in the Red Journal, 1975-2011.

PURPOSE Publication analysis has value in evaluating the mechanics of academic efforts in specific scientific communities. The specific aim of this study was to evaluate whether established bibliometric patterns seen in other academic fields were likewise observed in radiation oncology publication parameters. METHODS AND MATERIALS We used a commercial bibliographic database to analyze all pub...

Is there a good MAP for septic shock?

n engl j med 370;17 nejm.org april 24, 2014 1649 requirements that the American Board of Internal Medicine (ABIM) introduced in January 2014 require more effort than previous iterations. Completing NEJM Knowledge+ modules allows clinicians to earn both AMA PRA (American Medical Association Physician’s Recognition Award) Category 1 Credits and up 80 points toward the Self-Evaluation of Medical K...